You are discussing your exercise routine with a friend who's also interested in exercise. You recently started doing a new type of weight lifting exercises. Your friend asks you if it's been successful, and it has. You say:
It's made a noticeable difference.
A "noticeable" difference is a change that's big enough for you to see and notice. It's not as big as a "big difference" but maybe a little bit bigger than a "slight" difference.
Something "makes" a difference when it causes a situation to be different. The phrase "make a difference" is usually used for positive changes.
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