You're a successful doctor. You're giving advice to a high school student who thinks she might want to become a doctor. You're telling her what qualities are important for becoming a doctor. The first thing you say is:
Most importantly, you've got to be passionate about it.
When you're listing ideas, you can say which idea is most important by saying "Most importantly,..."
You can use this phrase to introduce the most important idea at the beginning of your list, or at the end. It's not common to use it for an idea in the middle of the list.
"Most importantly" can be used in written English or in slightly formal spoken situations, like when you're giving someone advice or discussing a topic in a business meeting.
"You've got to" is similar to "you need to". They're basically the same in meaning. However, "you've got to" is more common when talking about general qualities that you need in order to achieve a certain goal. For example:
You've got to be both talented and persistent to make it as an actor.
"You need to" is more common when you're actually telling the listener what they should do, right now.
You need to go talk to Mrs. Green about that.
You need to stop spending so much on entertainment and put some of that money toward your savings.
When you're "passionate" about something, it means that you care a lot and feel strongly about it. You use this phrase to describe your feelings about an idea, a subject area, or a social cause:
- passionate about the environment
- passionate about fashion
- passionate about helping young people to succeed in life
"Passionate" also can describe the feelings that lovers have toward each other.
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