“If there are any issues that require immediate attention, I can be reached on my mobile at 646-469-XXXX.”

You're going on vacation. You're leaving an e-mail out-of-office message to let people know that you won't answer their e-mails. But you include this line because you want people to call you if there's an emergency.

If there are any issues that require immediate attention, I can be reached on my mobile at 646-469-XXXX.

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issues that require immediate attention

"Issues" are problems. To "require" something means that you need it. "Immediate" means right now or very soon. And "attention" means noticing and dealing with something. So the meaning of this phrase is "problems that someone needs to deal with quickly". In the example above, the writer wants people to call her if they have a problem or question that they need her to take care of quickly.

Use this phrase in formal e-mails and written business documents.

"Attention" is the most common thing that people require. Other words that often follow "require" are:

  • require approval for something
  • require treatment
  • require assistance with something

(someone) can be reached at (a telephone number)

This is a formal phrase for giving out a telephone number:

I can be reached at 919-690-XXXX.

Use it in written English, especially in business situations.

To "reach" someone means to contact them and communicate with them. You can use the word "reach" to ask someone for a phone number or e-mail address:

Where can I reach you?