“Can I get change for a twenty?”

You have a twenty-dollar bill, but you need 20 one-dollar bills instead. You go to a bank and ask the teller this.

Can I get change for a twenty?

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get change for a (dollar/five/ten/twenty/hundred)

To "get change for ___" means to give someone a large bill, and get lots of smaller bills or coins in return.

You can say "change for a twenty". Or, if you want to be more formal, "change for a twenty-dollar bill":

Could I have change for a ten-dollar bill?