“Stick it in the microwave on 'defrost' for a few minutes.”
Your husband is going to cook dinner tonight, but he doesn't cook much so he doesn't know what to do. He has a frozen steak that needs to be thawed out. These are the instructions you give him.
Stick it in the microwave on 'defrost' for a few minutes.
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To "stick" something in a place means to put it there.
"Stick ___ ___" is more casual than "put" and also gives the impression of putting something quickly. For example, if someone is helping you move into a new house, you can tell them where to put a piece of furniture:
Just stick it over there in the corner.
In the example at top, the speaker says to "stick" the steak in the microwave because she's talking to her husband in a casual situation.
The microwave is a machine that heats food up really quickly. A more complete and formal name for it is "microwave oven".
When you're cooking or heating something in a microwave, you can use the expression "microwave (something)":
Microwave it for a couple minutes.
"Defrost" is one of the settings on a microwave oven. It's a setting that warms up frozen food slowly so that it doesn't get too hot and start to cook. There's also a "defrost" setting on car heating settings.