“Sure, I'd be glad to.”

A coworker asked if you would help her put together a presentation. You would like to help her because it seems like an interesting project. You say this to show your enthusiasm.

Sure, I'd be glad to.

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"Sure" means "yes".

A: Hey, can you help me with this?

B: Sure.

 But "sure" is more casual than "yes".

If you just answer "yes" to a question, it can sound as if you are angry:

A: Hey, can you help me with this?

B: Yes.

A: Uh... Are you annoyed or something?

"Sure" is similar to "of course". Both suggest that it's obvious and expected for the answer to be "yes".

A: Will you come to my graduation?

B: Of course!

"Of course" is a stronger response and more positive response than "sure".

I'd be glad to (do something)

When you want to cheerfully accept someone's request, you can say "I'd be glad to."

You can also follow "I'd be glad to" with a phrase describing the action that you'd be glad to do. For example, you can say:

I'd be glad to help you with that.

I'd be glad to teach you how to do it, if you're interested.

This is a good way to volunteer to do something. It sounds friendly and helpful.