“Can I drop these off here?”
You have some bags of used clothes that you want to donate to a thrift store. You want to know where to put the bags. You see an employee at the front of the store and ask this.
Can I drop these off here?
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Can I (do something)?
There are lots of different ways to ask for permission to do something:
Can I ___? May I ___? Would it be all right if I ___? Would you mind if I ___?
In the situation above, you don't need to be too polite. So "Can I ___?" is a good choice. Use "Can I ___?" when you want to do something that doesn't cause trouble for the other person. It's also good for asking questions of people that you're close to or on a similar social level with.
drop off (something)
To "drop off" something means to leave it in a place. But you only use it for things that you leave on purpose, not by accident. For example:
I need to swing by the office and drop off a few documents.
Could you drop this off for me at the post office?