“I'm totally obsessed with Glee.”
You're having lunch with a group of coworkers. The conversation turns to T.V. shows. You say this to express your opinion about your favorite show.
I'm totally obsessed with Glee.
I'm so sorry, I totally forgot to call you!
New Orleans was totally destroyed by the hurricane.
New York is totally different than it was back in the '80s.
Yes, I totally agree.
Evan's reaction was totally unexpected.
A slightly more formal word with a similar meaning is "completely". "Completely" could be used instead of "totally" in any of the examples above.
To be "obsessed with" something means to think about it constantly. For example, if a guy is "obsessed with" a girl, he will think about her all the time. He might talk about her a lot, or try to find out information about her. Other things that people can be "obsessed with" are:
...obsessed with sex
...obsessed with your weight
...obsessed with your appearance
The word "obsessed" doesn't have a very positive meaning when you use it to talk about someone else. But in the past few years people are using it more and more to talk about themselves. When you admit that you're "obsessed with" something, it means that you're really interested in it, and you don't stop thinking about it. For example, the PhraseMix profile page on Twitter says:
Obsessed with finding the best way to learn language.
If a person really likes a T.V. show, a comic book series, a fashion designer, etc., they might tell you that they're "obsessed with" it.