(an amount of money) in (a denomination)

Different types of bills (one-dollar bills, 100-dollar bills, etc.) are called "denominations". A very formal way to ask the question above is:

In what denomination would you like your change?

You use the word "in" to express the denomination of an amount of money:

Can I get that in twenties?

Drug dealers in movies always carry briefcases with thousands of dollars in hundred-dollar bills.

This phrase appears in these lessons: