“You need a solid foundation in basic math and science.”

You're a successful doctor. You're giving advice to a high school student who might want to become an doctor. You say this to explain what training and skills they will need.

You need a solid foundation in basic math and science.

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The word "you" doesn't always mean the person who you're directly speaking with. Sometimes it means "people in general" or "anyone".

Here are some examples of "you" used in a general way:

You need a solid foundation in basic math and science.

You can't beat face-to-face communication, you know?

In very formal English, you can use "one" instead of "you":

One is able to convey subtle nuances through face-to-face communication that are not possible to convey through other means.

a foundation in (something)

The "foundation" of a building is the part of the building at the very bottom that's connected to the ground. For a building to be strong, the foundation needs to be strong as well.

People often compare education to a building: in order to learn complicated things, you need to understand the basic ideas really well first. To explain this, people say that you need "a strong foundation in ___" or "a solid foundation in ___".

math and science

"Math" and "science" are often grouped together. You'll hear these words used together a lot. You can also hear them in the other order - "science and math"